Vapreotide
Also known as Sanvar
Vapreotide is a synthetic somatostatin analog with affinity for SSTR2 and SSTR5 receptors, studied primarily for acute esophageal variceal bleeding and for symptom control in neuroendocrine tumors. Compared with octreotide and lanreotide, it has more limited and geographically restricted regulatory approval, and it is not available in all markets. Clinical evidence is more limited than for the more widely used somatostatin analogs, so its role in practice remains narrower.
Reported benefits
- Studied for reduction of acute variceal hemorrhage
- Investigated for control of neuroendocrine tumor-related secretory symptoms
How it works
Vapreotide binds somatostatin receptor subtypes 2 and 5, reducing splanchnic blood flow and portal pressure while inhibiting secretion of growth hormone and various gastrointestinal hormones, similar in principle to other somatostatin analogs but with a distinct receptor-affinity profile.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 50 mcg | mcg/hour continuous IV infusion, as used in variceal bleeding trials |
| Moderate | 50 mcg | mcg IV bolus followed by continuous infusion |
| High | 100 mcg | mcg/hour in higher-intensity trial protocols |
Estimate your dose
Dose estimator
Educational estimate for Vapreotide, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Vapreotide. Educational only.
Draw to this mark
1units
= 0.01 mL for a 50 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
200
Under 2 units is hard to measure accurately. Use less water for a larger, easier-to-read draw.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Common protocols
Common questions
What is Vapreotide used for?
Vapreotide is a synthetic somatostatin analog with affinity for SSTR2 and SSTR5 receptors, studied primarily for acute esophageal variceal bleeding and for symptom control in neuroendocrine tumors. Compared with octreotide and lanreotide, it has more limited and geographically restricted regulatory approval, and it is not available in all markets. Clinical evidence is more limited than for the more widely used somatostatin analogs, so its role in practice remains narrower. Reported benefits include studied for reduction of acute variceal hemorrhage, investigated for control of neuroendocrine tumor-related secretory symptoms.
What is a typical Vapreotide dose?
Reported ranges run 50-100 mcg. A low protocol is 50 mcg mcg/hour continuous iv infusion, as used in variceal bleeding trials, and a high protocol is 100 mcg mcg/hour in higher-intensity trial protocols. This is reference information, not a dosing recommendation.
What is the half life of Vapreotide?
Approximately 30 to 70 minutes. That is what sets the dosing frequency, and it is why the timing guidance is as directed by your clinician.
How is Vapreotide administered?
Subcutaneous: into fat, under the skin. Primarily studied as an intravenous infusion for acute esophageal variceal bleeding; subcutaneous dosing has been studied for other indications. It is not FDA-approved in the United States and has narrower regulatory approval than octreotide or lanreotide.
How long is a Vapreotide cycle?
Acute short-course therapy over days for variceal bleeding on, followed by Discontinued once bleeding is controlled off. Not typically used as a chronic, self-administered peptide.
What are the side effects of Vapreotide?
Reported side effects include gastrointestinal disturbance, hyperglycemia, injection or infusion site reactions, bradycardia, gallbladder effects with prolonged use. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Vapreotide may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →