Triptorelin
Also known as Decapeptyl, Trelstar, Diphereline
Triptorelin is a synthetic GnRH agonist decapeptide formulated as a long-acting intramuscular depot. Like other GnRH agonists, it produces an initial gonadotropin surge followed by sustained pituitary desensitization, lowering testosterone or estrogen to castrate/menopausal levels within weeks. It is approved for advanced prostate cancer and used off-label or under separate approvals for endometriosis, central precocious puberty, and pituitary downregulation in assisted reproduction. Treatment duration and depot strength are determined by the prescribing physician based on the underlying condition.
Reported benefits
- Androgen deprivation for advanced prostate cancer
- Suppresses estrogen-driven pain in endometriosis
- Delays progression of central precocious puberty
- Enables pituitary downregulation in controlled ovarian stimulation (IVF) protocols
How it works
Continuous GnRH receptor agonism initially stimulates, then progressively desensitizes and downregulates, pituitary gonadotrope GnRH receptors. This shifts the axis from an initial LH/FSH surge (and transient rise in sex steroids) to sustained suppression of gonadotropin release and downstream sex-hormone production after roughly two to four weeks of therapy.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 3.75 mg | once monthly, IM depot |
| Moderate | 11.25 mg | once every 3 months, IM depot |
| High | 22.5 mg | once every 6 months, IM depot |
Estimate your dose
Dose estimator
Educational estimate for Triptorelin, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Triptorelin. Educational only.
Draw to this mark
225units
= 2.25 mL for a 11.25 mg dose
Concentration
5 mg/mL
Doses per vial
0
This dose needs 225 units, more than a 100-unit syringe holds. Add more water, split the dose, or use a larger syringe.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Common protocols
Common questions
What is Triptorelin used for?
Triptorelin is a synthetic GnRH agonist decapeptide formulated as a long-acting intramuscular depot. Like other GnRH agonists, it produces an initial gonadotropin surge followed by sustained pituitary desensitization, lowering testosterone or estrogen to castrate/menopausal levels within weeks. It is approved for advanced prostate cancer and used off-label or under separate approvals for endometriosis, central precocious puberty, and pituitary downregulation in assisted reproduction. Treatment duration and depot strength are determined by the prescribing physician based on the underlying condition. Reported benefits include androgen deprivation for advanced prostate cancer, suppresses estrogen-driven pain in endometriosis, delays progression of central precocious puberty.
What is a typical Triptorelin dose?
Reported ranges run 3.75-22.5 mg. A low protocol is 3.75 mg once monthly, im depot, and a high protocol is 22.5 mg once every 6 months, im depot. This is reference information, not a dosing recommendation.
What is the half life of Triptorelin?
Parent peptide half-life approximately 3 hours; depot formulation extends the effective suppressive duration to months. That is what sets the dosing frequency, and it is why the timing guidance is as directed by your clinician.
How is Triptorelin administered?
Intramuscular: into muscle. Administered as an intramuscular depot injection at monthly, 3-monthly, or 6-monthly intervals depending on the formulation used.
How long is a Triptorelin cycle?
Continuous per oncology or gynecologic protocol, often months to years on, followed by Discontinued only per prescriber decision off. Not a self-cycled research peptide; duration and depot strength are set by the treating physician.
What are the side effects of Triptorelin?
Reported side effects include initial disease/tumor symptom flare, hot flashes, decreased libido, reduced bone mineral density with prolonged use, injection site reactions. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Triptorelin may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →