Thymosin Alpha-1
Also known as Tα1, Zadaxin
Thymosin Alpha-1 is a 28-amino-acid peptide fragment derived from prothymosin alpha, naturally produced by the thymus gland. It is marketed in several countries (as Zadaxin) as an adjunct for chronic viral hepatitis and certain cancers, and has been studied for immune support in immunocompromised patients. Research interest centers on its potential to support T-cell maturation and modulate innate and adaptive immune responses. It is not FDA-approved in the United States, and use outside supervised clinical settings is investigational. This profile is educational only and is not medical advice.
Reported benefits
- May support immune resilience during chronic infection or immunosuppression
- Studied as an adjunct in some chronic viral hepatitis protocols
- May help modulate cytokine balance during immune dysregulation
- Explored as supportive care alongside certain cancer treatments
- May support vaccine response in some studied populations
How it works
Thymosin Alpha-1 interacts with toll-like receptors and modulates dendritic cell maturation, potentially supporting a balanced Th1/Th2 immune response. It appears to support thymocyte differentiation and may enhance natural killer cell and cytotoxic T-lymphocyte activity. It may also help regulate cytokine production, potentially tempering excessive inflammatory signaling while supporting pathogen clearance.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 800 mcg | twice weekly |
| Moderate | 1,600 mcg | twice weekly |
| High | 1,600 mcg | three times weekly |
Estimate your dose
Dose estimator
Educational estimate for Thymosin Alpha-1, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Thymosin Alpha-1. Educational only.
Draw to this mark
32units
= 0.32 mL for a 1,600 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
6
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Sometimes discussed alongside other immune-supportive peptides such as LL-37 or Thymulin; no established synergy data exists
Common protocols
Common questions
What is Thymosin Alpha-1 used for?
Thymosin Alpha-1 is a 28-amino-acid peptide fragment derived from prothymosin alpha, naturally produced by the thymus gland. It is marketed in several countries (as Zadaxin) as an adjunct for chronic viral hepatitis and certain cancers, and has been studied for immune support in immunocompromised patients. Research interest centers on its potential to support T-cell maturation and modulate innate and adaptive immune responses. It is not FDA-approved in the United States, and use outside supervised clinical settings is investigational. This profile is educational only and is not medical advice. Reported benefits include may support immune resilience during chronic infection or immunosuppression, studied as an adjunct in some chronic viral hepatitis protocols, may help modulate cytokine balance during immune dysregulation.
What is a typical Thymosin Alpha-1 dose?
Reported ranges run 800-1,600 mcg. A low protocol is 800 mcg twice weekly, and a high protocol is 1,600 mcg three times weekly. This is reference information, not a dosing recommendation.
What is the half life of Thymosin Alpha-1?
Approximately 2 hours in circulation, though downstream immune effects may persist longer. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is Thymosin Alpha-1 administered?
Subcutaneous: into fat, under the skin.
How long is a Thymosin Alpha-1 cycle?
4-12 weeks on, followed by 4 weeks off. Often cycled around periods of elevated infection risk or immune stress; continuous long-term use is not well studied
What are the side effects of Thymosin Alpha-1?
Reported side effects include injection site redness or irritation, mild flu-like symptoms in some users, headache, rare hypersensitivity reactions. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Thymosin Alpha-1 may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →