Tesofensine
Also known as NS2330
Tesofensine is an investigational oral compound that inhibits reuptake of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine. Originally studied for neurodegenerative conditions, it was found in early trials to reduce appetite and body weight, and has since been studied specifically for obesity. Reported average weight reductions in early trials were notable relative to some older appetite suppressants, though development has been slower than for injectable incretin therapies. It has not received widespread regulatory approval, and large-scale modern trial data remain limited compared with GLP-1-class agents.
Reported benefits
- Associated with appetite reduction and body-weight loss in early clinical trials
- Oral administration
- Distinct central-nervous-system mechanism from GLP-1-class agents
- Once-daily dosing schedule studied in trials
How it works
Tesofensine blocks presynaptic reuptake of serotonin, norepinephrine, and dopamine, increasing their availability in synapses within brain regions that regulate appetite and reward. This is thought to reduce food intake by altering hunger and satiety signaling as well as food-related reward response, distinguishing its mechanism from incretin-based agents.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 0.25 mg | once daily |
| Moderate | 0.5 mg | once daily |
| High | 1 mg | once daily |
Estimate your dose
Dose estimator
Educational estimate for Tesofensine, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Tesofensine. Educational only.
Draw to this mark
10units
= 0.1 mL for a 0.5 mg dose
Concentration
5 mg/mL
Doses per vial
20
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Combining with other stimulant-like or monoamine-active compounds is not supported by evidence and may increase cardiovascular risk.
Common protocols
Common questions
What is Tesofensine used for?
Tesofensine is an investigational oral compound that inhibits reuptake of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine. Originally studied for neurodegenerative conditions, it was found in early trials to reduce appetite and body weight, and has since been studied specifically for obesity. Reported average weight reductions in early trials were notable relative to some older appetite suppressants, though development has been slower than for injectable incretin therapies. It has not received widespread regulatory approval, and large-scale modern trial data remain limited compared with GLP-1-class agents. Reported benefits include associated with appetite reduction and body-weight loss in early clinical trials, oral administration, distinct central-nervous-system mechanism from glp-1-class agents.
What is a typical Tesofensine dose?
Reported ranges run 0.25-1 mg. A low protocol is 0.25 mg once daily, and a high protocol is 1 mg once daily. This is reference information, not a dosing recommendation.
What is the half life of Tesofensine?
Approximately 8 days, unusually long for an oral central-nervous-system agent. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is Tesofensine administered?
Oral: by mouth.
How long is a Tesofensine cycle?
Studied in trials over periods of roughly 6 months to 1 year on, followed by Not well established; extended use raises cardiovascular monitoring considerations off. Its long half-life means effects and side effects may persist well after the last dose.
What are the side effects of Tesofensine?
Reported side effects include increased heart rate and blood pressure reported in trials, dry mouth, nausea, constipation, and insomnia, potential mood or psychiatric effects given its central nervous system activity, long-term cardiovascular and psychiatric safety data remain limited. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Tesofensine may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →