Tesamorelin / MGF / Ipamorelin Blend
Also known as Tesa/MGF/Ipa Blend
This blend combines tesamorelin and ipamorelin, both studied for systemic GH/IGF-1 axis stimulation, with mechano growth factor (MGF), a splice variant of IGF-1 proposed to be locally expressed in skeletal muscle following mechanical stress or exercise-induced damage. MGF is the least established of the three components: most available information comes from animal studies and small mechanistic research rather than controlled human trials, and MGF is widely reported to be unstable once reconstituted. Of the growth-hormone blends discussed here, this combination has the most limited overall research base. It is primarily discussed in bodybuilding-adjacent research contexts rather than clinical literature, and it is not approved for human medical use.
Reported benefits
- Systemic growth-hormone axis stimulation
- Proposed local muscle-repair signaling from the MGF component
- Research interest in post-exercise recovery
- Supports body composition research goals
How it works
Tesamorelin and ipamorelin stimulate the systemic GH/IGF-1 axis via GHRH- and ghrelin-receptor pathways, respectively, as described for other blends in this category. MGF is proposed, based on preclinical work, to act locally within mechanically stressed muscle tissue to help trigger satellite cell activation and proliferation, a pathway distinct from circulating IGF-1 generated by liver GH signaling. Proponents describe the combination as pairing systemic GH-axis stimulation with a locally acting muscle-repair signal, though the degree of interaction between systemic and local IGF-1 pathways in humans has not been established.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 1,000 mcg | once daily, with the MGF portion typically reserved for post-workout use |
| Moderate | 1,800 mcg | once daily, with the MGF portion typically reserved for post-workout use |
| High | 2,500 mcg | once daily, with the MGF portion typically reserved for post-workout use |
Estimate your dose
Dose estimator
Educational estimate for Tesamorelin / MGF / Ipamorelin Blend, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Tesamorelin / MGF / Ipamorelin Blend. Educational only.
Draw to this mark
36units
= 0.36 mL for a 1,800 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
5
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
MGF has the most limited human research base of the components in this blend; it is frequently discussed in bodybuilding-adjacent contexts but lacks the clinical trial evidence of tesamorelin or the longer secretagogue research history of ipamorelin.
Common protocols
Common questions
What is Tesamorelin / MGF / Ipamorelin Blend used for?
This blend combines tesamorelin and ipamorelin, both studied for systemic GH/IGF-1 axis stimulation, with mechano growth factor (MGF), a splice variant of IGF-1 proposed to be locally expressed in skeletal muscle following mechanical stress or exercise-induced damage. MGF is the least established of the three components: most available information comes from animal studies and small mechanistic research rather than controlled human trials, and MGF is widely reported to be unstable once reconstituted. Of the growth-hormone blends discussed here, this combination has the most limited overall research base. It is primarily discussed in bodybuilding-adjacent research contexts rather than clinical literature, and it is not approved for human medical use. Reported benefits include systemic growth-hormone axis stimulation, proposed local muscle-repair signaling from the mgf component, research interest in post-exercise recovery.
What is a typical Tesamorelin / MGF / Ipamorelin Blend dose?
Reported ranges run 1,000-2,500 mcg. A low protocol is 1,000 mcg once daily, with the mgf portion typically reserved for post-workout use, and a high protocol is 2,500 mcg once daily, with the mgf portion typically reserved for post-workout use. This is reference information, not a dosing recommendation.
What is the half life of Tesamorelin / MGF / Ipamorelin Blend?
Tesamorelin is reported at roughly 25-40 minutes and ipamorelin at roughly 2 hours; MGF is reported to be extremely short-lived and unstable in solution, on the order of minutes, which is why some protocols reconstitute and dose it separately close to the time of use.. That is what sets the dosing frequency, and it is why the timing guidance is ~30 min before bed, empty stomach.
How is Tesamorelin / MGF / Ipamorelin Blend administered?
Subcutaneous: into fat, under the skin. Injected subcutaneously; some protocols dose the MGF component separately, immediately after exercise, rather than at the same fixed daily time as tesamorelin and ipamorelin.
How long is a Tesamorelin / MGF / Ipamorelin Blend cycle?
6-8 weeks on, followed by 6-8 weeks off. Shorter cycles than other GH blends are often suggested given the comparatively limited data on the MGF component.
What are the side effects of Tesamorelin / MGF / Ipamorelin Blend?
Reported side effects include injection site irritation, water retention, joint or muscle discomfort, inconsistent effect from the mgf component due to reported instability in solution, overall limited safety data relative to more established secretagogue blends. Evidence level for this compound is emerging research.
Partner offer · $20 off
When did you last
check your blood work?
Regular blood work catches changes early. At-home collection with free pickup, 50+ biomarkers, and results in 72 hours.
- 1Order your kitTakes two minutes online, $20 off with this link.
- 2Collect at homePainless draw with free home pickup, no lab visit.
- 3Results in 72 hours50+ biomarkers with clear optimal ranges.
Partner offer · opens rythm.health
Educational use only, not medical advice. This profile is provided for research and educational purposes. Tesamorelin / MGF / Ipamorelin Blend may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →