Survodutide
Also known as BI 456906
Survodutide is an investigational dual GLP-1/glucagon receptor agonist being studied for obesity and metabolic dysfunction-associated steatohepatitis (MASH). Phase 2 trials have reported meaningful average body-weight reductions alongside improvements in liver-related markers. It has not yet received regulatory approval and remains in late-stage clinical development. Evidence is currently limited to trial populations, and broader safety and efficacy data are still accumulating.
Reported benefits
- Associated with meaningful average weight loss in phase 2 trials
- May reduce liver fat content in studied populations
- Once-weekly dosing schedule
- Dual-pathway mechanism distinct from GLP-1-only agents
How it works
Survodutide activates GLP-1 receptors, producing appetite suppression and slowed gastric emptying, alongside glucagon receptor activation, which is thought to increase hepatic fat oxidation and energy expenditure. The combined action is intended to address both body weight and liver fat content, distinguishing it from single-pathway GLP-1 agents.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 0.6 mg | once weekly |
| Moderate | 2.4 mg | once weekly |
| High | 6 mg | once weekly |
Estimate your dose
Dose estimator
Educational estimate for Survodutide, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Survodutide. Educational only.
Draw to this mark
48units
= 0.48 mL for a 2.4 mg dose
Concentration
5 mg/mL
Doses per vial
4
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Not established; combination with other incretin-based agents is not supported by published research.
Common protocols
Common questions
What is Survodutide used for?
Survodutide is an investigational dual GLP-1/glucagon receptor agonist being studied for obesity and metabolic dysfunction-associated steatohepatitis (MASH). Phase 2 trials have reported meaningful average body-weight reductions alongside improvements in liver-related markers. It has not yet received regulatory approval and remains in late-stage clinical development. Evidence is currently limited to trial populations, and broader safety and efficacy data are still accumulating. Reported benefits include associated with meaningful average weight loss in phase 2 trials, may reduce liver fat content in studied populations, once-weekly dosing schedule.
What is a typical Survodutide dose?
Reported ranges run 0.6-6 mg. A low protocol is 0.6 mg once weekly, and a high protocol is 6 mg once weekly. This is reference information, not a dosing recommendation.
What is the half life of Survodutide?
Approximately 5-6 days, consistent with once-weekly dosing. That is what sets the dosing frequency, and it is why the timing guidance is weekly · same day, any time.
How is Survodutide administered?
Subcutaneous: into fat, under the skin.
How long is a Survodutide cycle?
Continuous use with titration over several months in trial protocols on, followed by Not established outside of trial settings off.
What are the side effects of Survodutide?
Reported side effects include nausea, vomiting, and diarrhea, especially during titration, decreased appetite, injection-site reactions, potential increases in heart rate reported in some trials, long-term safety data remain limited. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Survodutide may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →