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GH BlendsModerate evidence#5 in GH BlendsSubcutaneous · Into fat, under the skin

Sermorelin / GHRP-6 / GHRP-2 Blend

Also known as Triple Secretagogue Blend

This blend adds GHRP-6, a ghrelin-receptor agonist known for pronounced appetite stimulation, to the sermorelin/GHRP-2 combination. It is discussed mainly in the context of protocols emphasizing both GH release and increased caloric intake, such as informal mass-gain research. Because GHRP-6 and GHRP-2 both act at the ghrelin receptor, combining them targets an overlapping pathway rather than two distinct mechanisms, and the added benefit of using both together over either alone has not been directly studied. Sermorelin and GHRP-2 individually carry a longer research history; GHRP-6's appetite-driving properties are well documented, but the specific triple combination has limited dedicated research. It is not approved for human medical use.

Reported benefits

  • Stimulates a strong growth-hormone pulse
  • Associated with pronounced appetite stimulation, useful in mass-gain-oriented research contexts
  • Supports recovery
  • Reported to support sleep quality

How it works

Sermorelin stimulates the GHRH receptor as described for the sermorelin/GHRP-2 pairing. GHRP-6 and GHRP-2 both act at the ghrelin receptor (GHS-R1a); GHRP-6 is particularly associated with hypothalamic ghrelin-receptor activity that drives pronounced appetite stimulation, layered here alongside GHRP-2's GH-pulse effect. Proponents describe the combination as intensifying total ghrelin-receptor activation and appetite drive alongside GHRH-receptor stimulation, though this redundancy has not been formally compared with either GHRP used alone.

Dosing ranges

TierDoseFrequency
Low300 mcg2-3 times daily
Moderate450 mcg2-3 times daily
High700 mcg2-3 times daily

Estimate your dose

Dose estimator

Educational estimate for Sermorelin / GHRP-6 / GHRP-2 Blend, scaled to body size. Not medical advice.

Read before using

This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.

Mixing & syringe units

Target dose follows the estimate above. Change it there, or edit it directly below.

Reconstitution calculator

How much water to add and how many insulin-syringe units to draw for Sermorelin / GHRP-6 / GHRP-2 Blend. Educational only.

mL

Draw to this mark

9units

= 0.09 mL for a 450 mcg dose

0100 u (1 mL)

Concentration

5,000 mcg/mL

Doses per vial

22

A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.

Possible side effects

Pronounced increase in hungerWater retentionFlushingLethargyInjection site irritation

Stacking notes

Combining two ghrelin-receptor agonists (GHRP-6 and GHRP-2) is mechanistically redundant; proponents cite intensified appetite and GH response, though this has not been directly compared with either GHRP alone in controlled research.

Common protocols

Mass Gain StackAppetite & Recovery Protocol

Common questions

What is Sermorelin / GHRP-6 / GHRP-2 Blend used for?

This blend adds GHRP-6, a ghrelin-receptor agonist known for pronounced appetite stimulation, to the sermorelin/GHRP-2 combination. It is discussed mainly in the context of protocols emphasizing both GH release and increased caloric intake, such as informal mass-gain research. Because GHRP-6 and GHRP-2 both act at the ghrelin receptor, combining them targets an overlapping pathway rather than two distinct mechanisms, and the added benefit of using both together over either alone has not been directly studied. Sermorelin and GHRP-2 individually carry a longer research history; GHRP-6's appetite-driving properties are well documented, but the specific triple combination has limited dedicated research. It is not approved for human medical use. Reported benefits include stimulates a strong growth-hormone pulse, associated with pronounced appetite stimulation, useful in mass-gain-oriented research contexts, supports recovery.

What is a typical Sermorelin / GHRP-6 / GHRP-2 Blend dose?

Reported ranges run 300-700 mcg. A low protocol is 300 mcg 2-3 times daily, and a high protocol is 700 mcg 2-3 times daily. This is reference information, not a dosing recommendation.

What is the half life of Sermorelin / GHRP-6 / GHRP-2 Blend?

All three components are short-acting: sermorelin at roughly 10-20 minutes, GHRP-6 and GHRP-2 both at roughly 30-60 minutes, requiring multiple daily doses.. That is what sets the dosing frequency, and it is why the timing guidance is ~30 min before bed, empty stomach.

How is Sermorelin / GHRP-6 / GHRP-2 Blend administered?

Subcutaneous: into fat, under the skin. Injected subcutaneously, generally 2-3 times daily; the pronounced appetite effect of GHRP-6 leads many protocols to time doses around meals.

How long is a Sermorelin / GHRP-6 / GHRP-2 Blend cycle?

8-12 weeks on, followed by 4 weeks off. The pronounced appetite effect is often used as a practical cue for meal timing rather than a reason to shorten the cycle.

What are the side effects of Sermorelin / GHRP-6 / GHRP-2 Blend?

Reported side effects include pronounced increase in hunger, water retention, flushing, lethargy, injection site irritation. Evidence level for this compound is moderate evidence.

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Educational use only, not medical advice. This profile is provided for research and educational purposes. Sermorelin / GHRP-6 / GHRP-2 Blend may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →

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Educational use only. The information and calculators on this site are provided for research and educational purposes and are not medical advice, a diagnosis, a prescription, or a substitute for a licensed healthcare provider. Many compounds described are research compounds or prescription medicines not approved for general use. You must be 21 or older. Always consult a qualified clinician before making any health decision. Read the full disclaimer · Privacy Policy

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