Sermorelin / GHRP-2 Blend
Also known as Classic GH Blend
This blend pairs sermorelin, a truncated GHRH(1-29) analog with a long history in growth-hormone research, with GHRP-2, a potent ghrelin-receptor agonist. It represents one of the earliest and most extensively referenced secretagogue combinations, predating newer analogs such as CJC-1295 and ipamorelin. Sermorelin was previously marketed as an approved growth-hormone-deficiency treatment before that product was discontinued, giving it a comparatively long clinical research history; it is currently used as a compounded research peptide. GHRP-2 is studied as a more potent secretagogue than GHRP-6 with somewhat less pronounced appetite stimulation. The combined blend itself has not been evaluated in formal trials, though each component has an extensive individual research record.
Reported benefits
- Stimulates growth-hormone pulse via two distinct pathways
- Long individual research history for both components
- Reported to support sleep quality
- Associated with recovery and lean body composition research interest
How it works
Sermorelin binds the GHRH receptor, stimulating pulsatile GH release in a pattern intended to mirror endogenous GHRH signaling, with a short duration of action. GHRP-2 acts at the ghrelin receptor (GHS-R1a), producing a robust secretagogue effect with a comparatively moderate impact on appetite, cortisol, and prolactin relative to GHRP-6. Combined, the two pathways are described as producing a strong GH pulse when dosed together.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 200 mcg | 2-3 times daily |
| Moderate | 300 mcg | 2-3 times daily |
| High | 500 mcg | 2-3 times daily |
Estimate your dose
Dose estimator
Educational estimate for Sermorelin / GHRP-2 Blend, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Sermorelin / GHRP-2 Blend. Educational only.
Draw to this mark
6units
= 0.06 mL for a 300 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
33
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
A predecessor combination to CJC-1295/ipamorelin; some researchers still prefer it for its longer individual track record, though newer analogs are more commonly referenced today.
Common protocols
Common questions
What is Sermorelin / GHRP-2 Blend used for?
This blend pairs sermorelin, a truncated GHRH(1-29) analog with a long history in growth-hormone research, with GHRP-2, a potent ghrelin-receptor agonist. It represents one of the earliest and most extensively referenced secretagogue combinations, predating newer analogs such as CJC-1295 and ipamorelin. Sermorelin was previously marketed as an approved growth-hormone-deficiency treatment before that product was discontinued, giving it a comparatively long clinical research history; it is currently used as a compounded research peptide. GHRP-2 is studied as a more potent secretagogue than GHRP-6 with somewhat less pronounced appetite stimulation. The combined blend itself has not been evaluated in formal trials, though each component has an extensive individual research record. Reported benefits include stimulates growth-hormone pulse via two distinct pathways, long individual research history for both components, reported to support sleep quality.
What is a typical Sermorelin / GHRP-2 Blend dose?
Reported ranges run 200-500 mcg. A low protocol is 200 mcg 2-3 times daily, and a high protocol is 500 mcg 2-3 times daily. This is reference information, not a dosing recommendation.
What is the half life of Sermorelin / GHRP-2 Blend?
Sermorelin is reported at roughly 10-20 minutes and GHRP-2 at roughly 30-60 minutes; both are short-acting, requiring multiple daily doses to maintain a research protocol.. That is what sets the dosing frequency, and it is why the timing guidance is ~30 min before bed, empty stomach.
How is Sermorelin / GHRP-2 Blend administered?
Subcutaneous: into fat, under the skin. Injected subcutaneously, generally 2-3 times daily given the short duration of action of both components, often timed around meals and bedtime.
How long is a Sermorelin / GHRP-2 Blend cycle?
8-12 weeks on, followed by 4 weeks off. As one of the older secretagogue combinations, cycling recommendations largely mirror those developed for the newer CJC-1295/ipamorelin pairing.
What are the side effects of Sermorelin / GHRP-2 Blend?
Reported side effects include flushing, injection site reaction, mild appetite increase, water retention, headache. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Sermorelin / GHRP-2 Blend may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →