Semaglutide
Also known as Ozempic, Wegovy, Rybelsus
Semaglutide is a GLP-1 receptor agonist approved for type 2 diabetes and, at higher doses, for chronic weight management. It is one of the most extensively studied agents in this class, with multiple large randomized trials documenting its effects on body weight and glycemic control. It is administered by once-weekly subcutaneous injection, with an oral daily tablet formulation available for diabetes indications. Individual responses vary, and it is intended for use alongside lifestyle modification under medical supervision.
Reported benefits
- Associated with significant average body-weight reduction in clinical trials
- Improves glycemic control in type 2 diabetes
- May reduce certain cardiovascular risk markers in studied populations
- Once-weekly injection schedule with an oral alternative for diabetes
How it works
Semaglutide mimics the endogenous incretin hormone GLP-1, activating GLP-1 receptors in the pancreas, gut, and brain. This slows gastric emptying, increases feelings of fullness, and reduces appetite signaling in the hypothalamus, while also enhancing glucose-dependent insulin secretion.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 0.25 mg | once weekly |
| Moderate | 1 mg | once weekly |
| High | 2.4 mg | once weekly |
Estimate your dose
Dose estimator
Educational estimate for Semaglutide, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Semaglutide. Educational only.
Draw to this mark
20units
= 0.2 mL for a 1 mg dose
Concentration
5 mg/mL
Doses per vial
10
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Combining with other GLP-1 agents is not supported by evidence; combination with agents acting on different pathways (e.g., amylin analogs) has been studied in trials but should only occur under medical supervision.
Common protocols
Common questions
What is Semaglutide used for?
Semaglutide is a GLP-1 receptor agonist approved for type 2 diabetes and, at higher doses, for chronic weight management. It is one of the most extensively studied agents in this class, with multiple large randomized trials documenting its effects on body weight and glycemic control. It is administered by once-weekly subcutaneous injection, with an oral daily tablet formulation available for diabetes indications. Individual responses vary, and it is intended for use alongside lifestyle modification under medical supervision. Reported benefits include associated with significant average body-weight reduction in clinical trials, improves glycemic control in type 2 diabetes, may reduce certain cardiovascular risk markers in studied populations.
What is a typical Semaglutide dose?
Reported ranges run 0.25-2.4 mg. A low protocol is 0.25 mg once weekly, and a high protocol is 2.4 mg once weekly. This is reference information, not a dosing recommendation.
What is the half life of Semaglutide?
Approximately 7 days (168 hours), supporting once-weekly dosing. That is what sets the dosing frequency, and it is why the timing guidance is weekly · same day, any time.
How is Semaglutide administered?
Subcutaneous: into fat, under the skin. An oral tablet formulation (Rybelsus) is approved for diabetes and dosed daily; the subcutaneous formulation is the form most studied and approved for weight management.
How long is a Semaglutide cycle?
Continuous, ongoing use with titration per prescriber guidance on, followed by Not typically cycled off; discontinuation should be discussed with a prescriber off. Weight regain has been documented in follow-up studies after stopping treatment.
What are the side effects of Semaglutide?
Reported side effects include nausea, vomiting, diarrhea, and constipation, especially during titration, decreased appetite, risk of gallbladder-related events, injection-site reactions, labeled theoretical thyroid c-cell tumor risk based on animal studies. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Semaglutide may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →