PNC-27
PNC-27 is an experimental peptide derived from a fragment of the p53 tumor suppressor protein that is designed to bind HDM-2 (also called MDM2), a protein overexpressed on the cell membrane of many cancer cell types. It has been studied exclusively in laboratory settings, including in vitro cancer cell cultures and limited animal models, with the proposed goal of selectively killing cancer cells while sparing normal cells. No completed human clinical trials, FDA approval, or established human dosing exist for PNC-27, and it is not an approved or prescribed medication. Any human use occurs outside formal clinical research and regulatory oversight, and its safety and efficacy in humans are unverified.
Reported benefits
- Proposed selective cytotoxic activity against cancer cells in preclinical laboratory studies
- Investigated mechanism distinct from conventional chemotherapy, potentially relevant to future research
- Represents an active area of academic cancer-biology research
How it works
PNC-27 is designed to bind HDM-2 protein expressed on the outer membrane of cancer cells, a feature reportedly much less common on normal, non-cancerous cells. In laboratory studies, this binding has been proposed to trigger pore formation in the cancer cell membrane, leading to cell lysis and necrosis rather than the slower, more targeted process of apoptosis. Because this proposed mechanism relies on preferential HDM-2 membrane expression in cancer cells, its selectivity and effects have not been confirmed in human clinical studies.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 250 mcg | daily (informal/unregulated use only; no established clinical dosing exists) |
| Moderate | 500 mcg | daily (informal/unregulated use only; no established clinical dosing exists) |
| High | 1,000 mcg | daily (informal/unregulated use only; no established clinical dosing exists) |
Estimate your dose
Dose estimator
Educational estimate for PNC-27, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for PNC-27. Educational only.
Draw to this mark
10units
= 0.1 mL for a 500 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
20
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
No human safety or drug-interaction data exist; combining with other experimental compounds is unstudied and is discouraged outside formal, regulated research settings.
Common protocols
Common questions
What is PNC-27 used for?
PNC-27 is an experimental peptide derived from a fragment of the p53 tumor suppressor protein that is designed to bind HDM-2 (also called MDM2), a protein overexpressed on the cell membrane of many cancer cell types. It has been studied exclusively in laboratory settings, including in vitro cancer cell cultures and limited animal models, with the proposed goal of selectively killing cancer cells while sparing normal cells. No completed human clinical trials, FDA approval, or established human dosing exist for PNC-27, and it is not an approved or prescribed medication. Any human use occurs outside formal clinical research and regulatory oversight, and its safety and efficacy in humans are unverified. Reported benefits include proposed selective cytotoxic activity against cancer cells in preclinical laboratory studies, investigated mechanism distinct from conventional chemotherapy, potentially relevant to future research, represents an active area of academic cancer-biology research.
What is a typical PNC-27 dose?
Reported ranges run 250-1,000 mcg. A low protocol is 250 mcg daily (informal/unregulated use only; no established clinical dosing exists), and a high protocol is 1,000 mcg daily (informal/unregulated use only; no established clinical dosing exists). This is reference information, not a dosing recommendation.
What is the half life of PNC-27?
Not established in humans; likely short (on the order of minutes) based on its peptide size and structure, but this is unconfirmed. That is what sets the dosing frequency, and it is why the timing guidance is as directed by your clinician.
How is PNC-27 administered?
Subcutaneous: into fat, under the skin. No human clinical routes of administration have been established or approved; subcutaneous use reflects informal research-chemical practice, not a validated protocol.
How long is a PNC-27 cycle?
No established clinical protocol exists; informally reported use patterns describe courses lasting several weeks on, followed by No established or validated washout period exists off. PNC-27 has not completed human clinical trials; all available efficacy and safety data come from in vitro and limited animal studies. It is not an approved drug.
What are the side effects of PNC-27?
Reported side effects include no human safety data exist; potential risks in humans are unknown, effects observed only in vitro and in limited animal models may not translate to humans, unregulated research-chemical sourcing carries risks of impurity, mislabeling, or contamination, theoretical risk of unpredictable immune or tissue reactions given the lack of human testing. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. PNC-27 may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →