Mazdutide
Also known as IBI362, LY3305677
Mazdutide is a dual GLP-1/glucagon receptor agonist studied primarily in China for obesity and type 2 diabetes. Trials have reported meaningful average body-weight reductions and improvements in glycemic markers. Regulatory status varies by region, and it has not received broad international approval as of current published data. Evidence remains concentrated in specific trial populations, and independent confirmation across broader groups is ongoing.
Reported benefits
- Associated with meaningful average weight loss in clinical trials
- May improve glycemic control
- Once-weekly dosing schedule
- Dual-pathway mechanism targeting appetite and energy expenditure
How it works
Mazdutide activates GLP-1 receptors, reducing appetite and slowing gastric emptying, while also engaging glucagon receptors, which is thought to increase energy expenditure and support lipid metabolism. This dual mechanism is proposed to complement single-pathway GLP-1 agents by adding an energy-expenditure component.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 3 mg | once weekly |
| Moderate | 6 mg | once weekly |
| High | 9 mg | once weekly |
Estimate your dose
Dose estimator
Educational estimate for Mazdutide, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Mazdutide. Educational only.
Draw to this mark
120units
= 1.2 mL for a 6 mg dose
Concentration
5 mg/mL
Doses per vial
1
This dose needs 120 units, more than a 100-unit syringe holds. Add more water, split the dose, or use a larger syringe.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Not established; combination with other incretin-based agents is not supported by published research.
Common protocols
Common questions
What is Mazdutide used for?
Mazdutide is a dual GLP-1/glucagon receptor agonist studied primarily in China for obesity and type 2 diabetes. Trials have reported meaningful average body-weight reductions and improvements in glycemic markers. Regulatory status varies by region, and it has not received broad international approval as of current published data. Evidence remains concentrated in specific trial populations, and independent confirmation across broader groups is ongoing. Reported benefits include associated with meaningful average weight loss in clinical trials, may improve glycemic control, once-weekly dosing schedule.
What is a typical Mazdutide dose?
Reported ranges run 3-9 mg. A low protocol is 3 mg once weekly, and a high protocol is 9 mg once weekly. This is reference information, not a dosing recommendation.
What is the half life of Mazdutide?
Approximately 6 days, consistent with once-weekly dosing. That is what sets the dosing frequency, and it is why the timing guidance is weekly · same day, any time.
How is Mazdutide administered?
Subcutaneous: into fat, under the skin.
How long is a Mazdutide cycle?
Continuous use with titration over several months in trial protocols on, followed by Not established outside of trial settings off.
What are the side effects of Mazdutide?
Reported side effects include nausea, vomiting, and diarrhea, especially during titration, decreased appetite, injection-site reactions, potential increases in heart rate reported in some trials, long-term safety data remain limited outside of studied regions. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Mazdutide may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →