Leuprolide
Also known as Leuprorelin, Lupron, Eligard
Leuprolide is a long-acting synthetic GnRH agonist delivered as a depot injection, among the most widely used drugs in its class. It is approved for advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. Like other GnRH agonists, it causes an initial gonadotropin/testosterone or estrogen surge before sustained suppression develops over several weeks. Depot strengths allow dosing intervals from monthly to twice yearly.
Reported benefits
- Androgen deprivation therapy in advanced/metastatic prostate cancer
- Symptom control in endometriosis and uterine fibroids
- Management of central precocious puberty
- Used as an adjunct to radiation therapy in localized prostate cancer
How it works
Chronic exposure to leuprolide desensitizes pituitary GnRH receptors, reducing LH and FSH secretion and consequently lowering testosterone or estrogen to castrate or menopausal levels after an initial stimulatory flare phase.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 3.75 mg | once monthly depot |
| Moderate | 22.5 mg | once every 3 months depot |
| High | 45 mg | once every 6 months depot |
Estimate your dose
Dose estimator
Educational estimate for Leuprolide, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Leuprolide. Educational only.
Draw to this mark
450units
= 4.5 mL for a 22.5 mg dose
Concentration
5 mg/mL
Doses per vial
0
This dose needs 450 units, more than a 100-unit syringe holds. Add more water, split the dose, or use a larger syringe.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Common protocols
Common questions
What is Leuprolide used for?
Leuprolide is a long-acting synthetic GnRH agonist delivered as a depot injection, among the most widely used drugs in its class. It is approved for advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. Like other GnRH agonists, it causes an initial gonadotropin/testosterone or estrogen surge before sustained suppression develops over several weeks. Depot strengths allow dosing intervals from monthly to twice yearly. Reported benefits include androgen deprivation therapy in advanced/metastatic prostate cancer, symptom control in endometriosis and uterine fibroids, management of central precocious puberty.
What is a typical Leuprolide dose?
Reported ranges run 3.75-45 mg. A low protocol is 3.75 mg once monthly depot, and a high protocol is 45 mg once every 6 months depot. This is reference information, not a dosing recommendation.
What is the half life of Leuprolide?
Parent compound approximately 3 hours; depot formulations provide sustained release over 1 to 6 months. That is what sets the dosing frequency, and it is why the timing guidance is as directed by your clinician.
How is Leuprolide administered?
Intramuscular: into muscle. Available as intramuscular or subcutaneous depot formulations depending on brand (e.g., Lupron Depot is IM, Eligard is subcutaneous); dosing interval is set by depot strength.
How long is a Leuprolide cycle?
Continuous per oncology protocol; often long-term or indefinite for metastatic disease on, followed by Discontinued per prescriber decision off. Duration is individualized by the treating physician; not a self-cycled peptide.
What are the side effects of Leuprolide?
Reported side effects include initial symptom/tumor flare, hot flashes, bone mineral density loss with long-term use, injection site reactions, mood changes. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Leuprolide may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →