Lanreotide
Also known as Somatuline
Lanreotide is a long-acting synthetic somatostatin analog approved for acromegaly and for neuroendocrine tumors, including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). It reduces excess growth hormone and IGF-1 secretion in acromegaly and helps control hormone-driven symptoms and, in some cases, tumor growth in functioning neuroendocrine tumors. It is formulated as a deep subcutaneous depot gel dosed roughly monthly. As a somatostatin analog, its physiologic effects extend well beyond growth hormone to other gut and pancreatic hormones.
Reported benefits
- Normalizes GH and IGF-1 levels in acromegaly
- Controls flushing and diarrhea in carcinoid/neuroendocrine tumor syndromes
- May slow tumor growth in some gastroenteropancreatic neuroendocrine tumors
- Long-acting monthly dosing improves adherence
How it works
Lanreotide binds somatostatin receptors, predominantly SSTR2 with some SSTR5 affinity, on pituitary somatotroph cells and neuroendocrine tissue. Receptor activation inhibits growth hormone, IGF-1, and various gastrointestinal/pancreatic hormone secretion via Gi-coupled signaling that reduces cyclic AMP.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 60 mg | every 4 weeks, deep subcutaneous |
| Moderate | 90 mg | every 4 weeks |
| High | 120 mg | every 4 weeks |
Estimate your dose
Dose estimator
Educational estimate for Lanreotide, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Lanreotide. Educational only.
Draw to this mark
1,800units
= 18 mL for a 90 mg dose
Concentration
5 mg/mL
Doses per vial
0
This dose needs 1,800 units, more than a 100-unit syringe holds. Add more water, split the dose, or use a larger syringe.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Common protocols
Common questions
What is Lanreotide used for?
Lanreotide is a long-acting synthetic somatostatin analog approved for acromegaly and for neuroendocrine tumors, including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). It reduces excess growth hormone and IGF-1 secretion in acromegaly and helps control hormone-driven symptoms and, in some cases, tumor growth in functioning neuroendocrine tumors. It is formulated as a deep subcutaneous depot gel dosed roughly monthly. As a somatostatin analog, its physiologic effects extend well beyond growth hormone to other gut and pancreatic hormones. Reported benefits include normalizes gh and igf-1 levels in acromegaly, controls flushing and diarrhea in carcinoid/neuroendocrine tumor syndromes, may slow tumor growth in some gastroenteropancreatic neuroendocrine tumors.
What is a typical Lanreotide dose?
Reported ranges run 60-120 mg. A low protocol is 60 mg every 4 weeks, deep subcutaneous, and a high protocol is 120 mg every 4 weeks. This is reference information, not a dosing recommendation.
What is the half life of Lanreotide?
Approximately 23 to 30 days for the depot formulation. That is what sets the dosing frequency, and it is why the timing guidance is as directed by your clinician.
How is Lanreotide administered?
Subcutaneous: into fat, under the skin. Deep subcutaneous injection, typically into the superior external quadrant of the buttock, usually administered by a healthcare provider.
How long is a Lanreotide cycle?
Continuous monthly dosing, often long-term or indefinite depending on the condition on, followed by Discontinued per prescriber decision off.
What are the side effects of Lanreotide?
Reported side effects include gastrointestinal upset, including diarrhea and abdominal pain, gallstone formation with long-term use, injection site nodules, altered glucose tolerance or hyperglycemia, bradycardia. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Lanreotide may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →