KPV
KPV is a tripeptide (Lysine-Proline-Valine) representing the C-terminal fragment of alpha-melanocyte-stimulating hormone, retaining much of the parent molecule's anti-inflammatory activity without its pigmentation effects. It has been studied primarily in animal models of inflammatory bowel disease, colitis, and skin inflammation. Research interest centers on its apparent ability to suppress pro-inflammatory signaling without the broader hormonal effects associated with full-length alpha-MSH. Human clinical trial data remain limited, and KPV is not an approved pharmaceutical therapy.
Reported benefits
- Studied in animal models of colitis and inflammatory bowel disease
- Explored for skin-related inflammatory conditions
- May help modulate NF-kB-driven cytokine production
- Investigated for supportive wound-healing effects alongside inflammation control
How it works
KPV appears to inhibit nuclear factor kappa-B (NF-kB) signaling, a central regulator of pro-inflammatory gene expression, reducing downstream production of cytokines such as TNF-alpha and IL-6. Unlike full alpha-MSH, KPV does not require melanocortin receptor engagement for many of its effects, suggesting an additional receptor-independent anti-inflammatory pathway. It has also been studied for direct antimicrobial activity in some models.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 200 mcg | daily |
| Moderate | 500 mcg | daily |
| High | 1,000 mcg | daily |
Estimate your dose
Dose estimator
Educational estimate for KPV, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for KPV. Educational only.
Draw to this mark
10units
= 0.1 mL for a 500 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
20
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Frequently discussed alongside BPC-157 for combined gut-healing and anti-inflammatory research protocols
Common protocols
Common questions
What is KPV used for?
KPV is a tripeptide (Lysine-Proline-Valine) representing the C-terminal fragment of alpha-melanocyte-stimulating hormone, retaining much of the parent molecule's anti-inflammatory activity without its pigmentation effects. It has been studied primarily in animal models of inflammatory bowel disease, colitis, and skin inflammation. Research interest centers on its apparent ability to suppress pro-inflammatory signaling without the broader hormonal effects associated with full-length alpha-MSH. Human clinical trial data remain limited, and KPV is not an approved pharmaceutical therapy. Reported benefits include studied in animal models of colitis and inflammatory bowel disease, explored for skin-related inflammatory conditions, may help modulate nf-kb-driven cytokine production.
What is a typical KPV dose?
Reported ranges run 200-1,000 mcg. A low protocol is 200 mcg daily, and a high protocol is 1,000 mcg daily. This is reference information, not a dosing recommendation.
What is the half life of KPV?
Short, estimated at under 30 minutes, consistent with other small unmodified tripeptides. That is what sets the dosing frequency, and it is why the timing guidance is morning, or split am/pm.
How is KPV administered?
Subcutaneous: into fat, under the skin.
How long is a KPV cycle?
4-8 weeks on, followed by 4 weeks off. Often used during active flares of inflammatory symptoms rather than continuously
What are the side effects of KPV?
Reported side effects include injection site irritation, limited human safety and long-term data, theoretical gastrointestinal effects with oral or compounded forms, rare hypersensitivity. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. KPV may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →