Ipamorelin
Also known as NNC 26-0161
Ipamorelin is a selective growth hormone releasing peptide developed to stimulate GH secretion while largely avoiding the cortisol, prolactin, and appetite effects seen with earlier GHRPs. It has been studied in clinical trials, including for gastrointestinal motility applications, and is widely used in research and community protocols due to its comparatively clean side-effect profile. Its GH-releasing magnitude per dose is generally reported as more modest than GHRP-2, GHRP-6, or hexarelin, but its tolerability has made it a common choice for extended use. It is frequently combined with a GHRH analog to amplify the GH pulse.
Reported benefits
- Selective GH release with minimal off-target effects
- Improved sleep quality
- Supports recovery and lean mass
- Generally well tolerated for extended use
How it works
Ipamorelin selectively activates the growth hormone secretagogue receptor (GHS-R1a) to stimulate pulsatile GH release from the pituitary. Unlike earlier GHRPs, it shows minimal activity on pathways linked to cortisol, prolactin, or the hunger-driving effects of ghrelin signaling, which researchers attribute to its more selective receptor binding profile.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 100 mcg | once daily |
| Moderate | 200 mcg | twice daily |
| High | 300 mcg | three times daily |
Estimate your dose
Dose estimator
Educational estimate for Ipamorelin, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Ipamorelin. Educational only.
Draw to this mark
4units
= 0.04 mL for a 200 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
50
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Most commonly stacked with CJC-1295 (with or without DAC); favored in stacks where cortisol, prolactin, or appetite side effects are undesirable.
Common protocols
Common questions
What is Ipamorelin used for?
Ipamorelin is a selective growth hormone releasing peptide developed to stimulate GH secretion while largely avoiding the cortisol, prolactin, and appetite effects seen with earlier GHRPs. It has been studied in clinical trials, including for gastrointestinal motility applications, and is widely used in research and community protocols due to its comparatively clean side-effect profile. Its GH-releasing magnitude per dose is generally reported as more modest than GHRP-2, GHRP-6, or hexarelin, but its tolerability has made it a common choice for extended use. It is frequently combined with a GHRH analog to amplify the GH pulse. Reported benefits include selective gh release with minimal off-target effects, improved sleep quality, supports recovery and lean mass.
What is a typical Ipamorelin dose?
Reported ranges run 100-300 mcg. A low protocol is 100 mcg once daily, and a high protocol is 300 mcg three times daily. This is reference information, not a dosing recommendation.
What is the half life of Ipamorelin?
~2 hours. That is what sets the dosing frequency, and it is why the timing guidance is ~30 min before bed, empty stomach.
How is Ipamorelin administered?
Subcutaneous: into fat, under the skin. Injected subcutaneously, commonly before bed or post-workout
How long is a Ipamorelin cycle?
8-12 weeks on, followed by 4 weeks off. Reported desensitization is minimal compared to other GHRPs, though cycling remains common practice
What are the side effects of Ipamorelin?
Reported side effects include mild headache, injection-site redness, mild water retention, rare dizziness. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Ipamorelin may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →