Humanin
Humanin is a short mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA gene region, first identified through research on Alzheimer's-disease-resistant neurons. It has since been studied for broader roles in cellular stress resistance, metabolic regulation, and protection against oxidative damage. Research spans cell culture, animal models, and a smaller body of observational human studies correlating circulating humanin levels with age and disease states. It remains primarily a research compound, and synthetic humanin analogs used outside clinical trials are not regulated therapeutics.
Reported benefits
- Studied for potential neuroprotective effects against oxidative and beta-amyloid stress
- Explored for roles in mitochondrial and metabolic health
- May support cellular stress resistance in preclinical models
- Investigated as a biomarker and potential target in age-related research
How it works
Humanin is proposed to bind cell-surface receptor complexes, including formyl peptide receptor-like 1, to activate intracellular survival signaling pathways such as STAT3 and AMPK. This signaling may help protect cells against apoptosis triggered by oxidative stress or beta-amyloid exposure. It has also been studied for potential roles in mitochondrial quality control and systemic metabolic regulation.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 1 mg | daily |
| Moderate | 2 mg | daily |
| High | 4 mg | daily |
Estimate your dose
Dose estimator
Educational estimate for Humanin, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Humanin. Educational only.
Draw to this mark
40units
= 0.4 mL for a 2 mg dose
Concentration
5 mg/mL
Doses per vial
5
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Sometimes discussed alongside other mitochondria-focused peptides such as SS-31; combination effects are not studied in humans
Common protocols
Common questions
What is Humanin used for?
Humanin is a short mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA gene region, first identified through research on Alzheimer's-disease-resistant neurons. It has since been studied for broader roles in cellular stress resistance, metabolic regulation, and protection against oxidative damage. Research spans cell culture, animal models, and a smaller body of observational human studies correlating circulating humanin levels with age and disease states. It remains primarily a research compound, and synthetic humanin analogs used outside clinical trials are not regulated therapeutics. Reported benefits include studied for potential neuroprotective effects against oxidative and beta-amyloid stress, explored for roles in mitochondrial and metabolic health, may support cellular stress resistance in preclinical models.
What is a typical Humanin dose?
Reported ranges run 1-4 mg. A low protocol is 1 mg daily, and a high protocol is 4 mg daily. This is reference information, not a dosing recommendation.
What is the half life of Humanin?
Short, estimated at under 30 minutes in circulating form. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is Humanin administered?
Subcutaneous: into fat, under the skin.
How long is a Humanin cycle?
4-8 weeks on, followed by 4 weeks off. No standardized cycling protocol exists; timelines are extrapolated from general peptide-research practice
What are the side effects of Humanin?
Reported side effects include limited human safety data, injection site irritation possible, theoretical concerns given its role in cell survival signaling and cancer biology, unknown long-term effects. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Humanin may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →