GHRP-2
Also known as Pralmorelin, KP-102
GHRP-2 is a synthetic hexapeptide-class growth hormone secretagogue that acts on the ghrelin receptor to stimulate pituitary growth hormone release. It has been studied since the 1990s, including as a diagnostic agent for growth hormone deficiency testing. Research suggests it produces a reliable, dose-dependent GH pulse with moderate effects on appetite, cortisol, and prolactin. It is commonly used in research and community protocols aimed at recovery, sleep quality, and body composition support.
Reported benefits
- Increased GH/IGF-1 output
- Improved recovery and sleep quality
- Modest lean mass support
- Mild to moderate appetite stimulation
How it works
GHRP-2 binds the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary, mimicking endogenous ghrelin to trigger a pulse of growth hormone release. This pathway is distinct from, and reported to synergize with, growth hormone releasing hormone (GHRH) signaling. Activation of GHS-R1a also modestly raises ACTH/cortisol and prolactin and stimulates appetite via hypothalamic ghrelin signaling.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 100 mcg | once daily |
| Moderate | 200 mcg | twice daily |
| High | 300 mcg | three times daily |
Estimate your dose
Dose estimator
Educational estimate for GHRP-2, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for GHRP-2. Educational only.
Draw to this mark
4units
= 0.04 mL for a 200 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
50
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Commonly paired with a GHRH analog (CJC-1295 or Sermorelin) for synergistic GH pulse amplitude; not typically combined with exogenous GH.
Common protocols
Common questions
What is GHRP-2 used for?
GHRP-2 is a synthetic hexapeptide-class growth hormone secretagogue that acts on the ghrelin receptor to stimulate pituitary growth hormone release. It has been studied since the 1990s, including as a diagnostic agent for growth hormone deficiency testing. Research suggests it produces a reliable, dose-dependent GH pulse with moderate effects on appetite, cortisol, and prolactin. It is commonly used in research and community protocols aimed at recovery, sleep quality, and body composition support. Reported benefits include increased gh/igf-1 output, improved recovery and sleep quality, modest lean mass support.
What is a typical GHRP-2 dose?
Reported ranges run 100-300 mcg. A low protocol is 100 mcg once daily, and a high protocol is 300 mcg three times daily. This is reference information, not a dosing recommendation.
What is the half life of GHRP-2?
~30 min. That is what sets the dosing frequency, and it is why the timing guidance is ~30 min before bed, empty stomach.
How is GHRP-2 administered?
Subcutaneous: into fat, under the skin. Injected subcutaneously into abdominal fat, typically on an empty stomach
How long is a GHRP-2 cycle?
8-12 weeks on, followed by 4 weeks off. Cycling is commonly used to offset reported ghrelin-receptor desensitization and appetite/cortisol creep
What are the side effects of GHRP-2?
Reported side effects include increased hunger, water retention or mild edema, transient cortisol/prolactin elevation, injection-site irritation, tingling or flushing. Evidence level for this compound is well studied.
Partner offer · $20 off
When did you last
check your blood work?
Regular blood work catches changes early. At-home collection with free pickup, 50+ biomarkers, and results in 72 hours.
- 1Order your kitTakes two minutes online, $20 off with this link.
- 2Collect at homePainless draw with free home pickup, no lab visit.
- 3Results in 72 hours50+ biomarkers with clear optimal ranges.
Partner offer · opens rythm.health
Educational use only, not medical advice. This profile is provided for research and educational purposes. GHRP-2 may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →