Enclomiphene
Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) studied for its ability to raise endogenous testosterone production without directly introducing exogenous hormone. It has been researched as an alternative to testosterone replacement therapy in men seeking to preserve fertility and natural hormone production. Unlike injectable testosterone, enclomiphene works upstream by influencing the hypothalamic-pituitary-gonadal axis. It has been evaluated in clinical trials for secondary hypogonadism but is not universally approved as a standalone prescription product in all markets. Long-term outcome data compared to established testosterone therapies remains an active area of research.
Reported benefits
- Studied for raising endogenous testosterone without suppressing natural production
- May help preserve fertility and testicular function compared to exogenous testosterone
- Oral administration avoids the need for injections
- Investigated as an option for men wanting to avoid the feedback suppression associated with testosterone replacement therapy
How it works
Enclomiphene selectively blocks estrogen receptors in the hypothalamus, interrupting the negative feedback signal that estrogen normally provides. This leads to increased release of GnRH, which in turn raises luteinizing hormone and follicle-stimulating hormone output from the pituitary, stimulating the testes to increase natural testosterone production.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 6.25 mg | once daily |
| Moderate | 12.5 mg | once daily |
| High | 25 mg | once daily, at the upper end of ranges studied in clinical trials |
Estimate your dose
Dose estimator
Educational estimate for Enclomiphene, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Enclomiphene. Educational only.
Draw to this mark
250units
= 2.5 mL for a 12.5 mg dose
Concentration
5 mg/mL
Doses per vial
0
This dose needs 250 units, more than a 100-unit syringe holds. Add more water, split the dose, or use a larger syringe.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Sometimes discussed alongside aromatase inhibitors to manage estradiol levels as testosterone rises; such combinations should only be considered with hormone panel monitoring and prescriber guidance.
Common protocols
Common questions
What is Enclomiphene used for?
Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) studied for its ability to raise endogenous testosterone production without directly introducing exogenous hormone. It has been researched as an alternative to testosterone replacement therapy in men seeking to preserve fertility and natural hormone production. Unlike injectable testosterone, enclomiphene works upstream by influencing the hypothalamic-pituitary-gonadal axis. It has been evaluated in clinical trials for secondary hypogonadism but is not universally approved as a standalone prescription product in all markets. Long-term outcome data compared to established testosterone therapies remains an active area of research. Reported benefits include studied for raising endogenous testosterone without suppressing natural production, may help preserve fertility and testicular function compared to exogenous testosterone, oral administration avoids the need for injections.
What is a typical Enclomiphene dose?
Reported ranges run 6.25-25 mg. A low protocol is 6.25 mg once daily, and a high protocol is 25 mg once daily, at the upper end of ranges studied in clinical trials. This is reference information, not a dosing recommendation.
What is the half life of Enclomiphene?
Reported at approximately 10 hours in available pharmacokinetic studies, though estimates vary across sources.. That is what sets the dosing frequency, and it is why the timing guidance is morning, daily.
How is Enclomiphene administered?
Oral: by mouth. Taken as an oral tablet or capsule; not injected.
How long is a Enclomiphene cycle?
Multi-week to multi-month continuous daily use has been studied in clinical trials on, followed by Discontinuation protocols and required off-periods are not well standardized and should be guided by hormone panel monitoring off. Regular bloodwork to monitor testosterone, estradiol, and LH/FSH is commonly recommended when using SERMs for hormone modulation.
What are the side effects of Enclomiphene?
Reported side effects include visual disturbances, reported more commonly with related compound clomiphene, mood changes, including irritability, hot flashes, potential for elevated estradiol in some individuals as testosterone rises, headache. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Enclomiphene may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →