Dihexa / Tesofensine Blend
Also known as Dihexa-Tesofensine Stack, DT Nootropic Blend
Dihexa / Tesofensine Blend pairs two structurally unrelated compounds studied for effects on brain function: Dihexa, a small molecule derived from angiotensin IV studied preclinically for synaptogenesis and memory support, and Tesofensine, a triple monoamine (serotonin, norepinephrine, dopamine) reuptake inhibitor originally investigated as a weight-management and Parkinson's disease drug candidate. The blend is marketed on the premise that Dihexa's proposed neuroregenerative activity may complement Tesofensine's stimulant-like effects on alertness, motivation, and mood. Evidence for either compound in humans is limited, and no study has evaluated this specific combination. Tesofensine carries a documented cardiovascular signal in clinical trials, including increases in heart rate, which is part of why it was not ultimately approved as a weight-loss therapy in the markets where it was studied.
Reported benefits
- Tesofensine's monoamine reuptake inhibition is studied for increased alertness, motivation, and appetite suppression
- Dihexa is studied preclinically for synaptogenesis and memory-related support
- Delivered as a single combined product rather than sourcing two separate research compounds
- May appeal to users interested in both cognitive and stimulant-like effects
How it works
Dihexa is proposed to potentiate hepatocyte growth factor (HGF) activity at its c-Met receptor, a pathway linked in preclinical models to new synapse formation. Tesofensine inhibits presynaptic reuptake of serotonin, norepinephrine, and dopamine, increasing synaptic availability of all three, which is thought to underlie its studied effects on appetite suppression, energy, and mood. The blend combines a proposed neuroregenerative mechanism with a monoamine-based stimulant mechanism; these pathways have not been studied together, and possible interactions are not characterized.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 125 mcg | once daily |
| Moderate | 250 mcg | once daily |
| High | 500 mcg | once daily, occasionally split |
Estimate your dose
Dose estimator
Educational estimate for Dihexa / Tesofensine Blend, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Dihexa / Tesofensine Blend. Educational only.
Draw to this mark
5units
= 0.05 mL for a 250 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
40
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Combining this blend with other stimulants, monoamine-active compounds, or MAOIs is generally discouraged given tesofensine's cardiovascular profile. Anyone considering use alongside other medications should seek individualized medical guidance rather than relying on informal protocols.
Common protocols
Common questions
What is Dihexa / Tesofensine Blend used for?
Dihexa / Tesofensine Blend pairs two structurally unrelated compounds studied for effects on brain function: Dihexa, a small molecule derived from angiotensin IV studied preclinically for synaptogenesis and memory support, and Tesofensine, a triple monoamine (serotonin, norepinephrine, dopamine) reuptake inhibitor originally investigated as a weight-management and Parkinson's disease drug candidate. The blend is marketed on the premise that Dihexa's proposed neuroregenerative activity may complement Tesofensine's stimulant-like effects on alertness, motivation, and mood. Evidence for either compound in humans is limited, and no study has evaluated this specific combination. Tesofensine carries a documented cardiovascular signal in clinical trials, including increases in heart rate, which is part of why it was not ultimately approved as a weight-loss therapy in the markets where it was studied. Reported benefits include tesofensine's monoamine reuptake inhibition is studied for increased alertness, motivation, and appetite suppression, dihexa is studied preclinically for synaptogenesis and memory-related support, delivered as a single combined product rather than sourcing two separate research compounds.
What is a typical Dihexa / Tesofensine Blend dose?
Reported ranges run 125-500 mcg. A low protocol is 125 mcg once daily, and a high protocol is 500 mcg once daily, occasionally split. This is reference information, not a dosing recommendation.
What is the half life of Dihexa / Tesofensine Blend?
Tesofensine has a long reported elimination half-life in humans, spanning several days due to an active metabolite, while Dihexa's half-life in humans has not been formally established, though its small, lipophilic structure suggests rapid distribution and clearance.. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is Dihexa / Tesofensine Blend administered?
Subcutaneous: into fat, under the skin. Tesofensine has been studied clinically as an oral compound, but this blend is formulated for subcutaneous co-administration with Dihexa.
How long is a Dihexa / Tesofensine Blend cycle?
4 weeks on, followed by 2-4 weeks off. Given tesofensine's cardiovascular signal and long half-life, conservative sources describe shorter on-periods with attention to heart rate and blood pressure. Combination-specific cycling has not been studied.
What are the side effects of Dihexa / Tesofensine Blend?
Reported side effects include increased heart rate and blood pressure, a documented effect of tesofensine in clinical trials, insomnia or overstimulation, appetite suppression, injection site irritation, dihexa's human side-effect profile is not well characterized due to limited clinical data. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Dihexa / Tesofensine Blend may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →