Dihexa
Dihexa is a synthetic small molecule derived from angiotensin IV, designed to mimic and amplify neurotrophic activity through the hepatocyte growth factor (HGF)/c-Met signaling pathway. It has attracted research interest for its reported potency in promoting synapse formation at very low doses in preclinical models, positioning it as a candidate for cognitive and neurodegenerative research rather than an established therapeutic. Human clinical data are essentially absent, with almost all available evidence coming from cell culture and animal studies. Original research characterized it as active via non-injectable routes in animal models, though it is supplied and discussed here as an injectable research compound. Given the early stage of research, claims about cognitive benefit in humans should be treated with substantial caution.
Reported benefits
- Preclinical models report potent effects on synapse formation at very low doses
- Explored as a research tool for models of cognitive impairment
- Investigated for potential neuroregenerative activity after neuronal injury in animal studies
- Proposed as a candidate compound for neurodegenerative disease research
How it works
Dihexa is proposed to potentiate HGF/c-Met signaling, a pathway involved in synaptogenesis and neuronal survival during development and in response to injury. By amplifying this pathway at concentrations far lower than HGF itself, it is theorized in animal models to promote formation of new synaptic connections relevant to learning and memory. The relevance and safety of chronically activating this growth-factor pathway in humans has not been established.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 5 mcg | once daily |
| Moderate | 10 mcg | once daily |
| High | 20 mcg | once daily |
Estimate your dose
Dose estimator
Educational estimate for Dihexa, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Dihexa. Educational only.
Draw to this mark
0.2units
= 0.002 mL for a 10 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
1,000
Under 2 units is hard to measure accurately. Use less water for a larger, easier-to-read draw.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Sometimes mentioned alongside other neurotrophic-focused peptides in research discussions; no data exist on interactions or combined effects.
Common protocols
Common questions
What is Dihexa used for?
Dihexa is a synthetic small molecule derived from angiotensin IV, designed to mimic and amplify neurotrophic activity through the hepatocyte growth factor (HGF)/c-Met signaling pathway. It has attracted research interest for its reported potency in promoting synapse formation at very low doses in preclinical models, positioning it as a candidate for cognitive and neurodegenerative research rather than an established therapeutic. Human clinical data are essentially absent, with almost all available evidence coming from cell culture and animal studies. Original research characterized it as active via non-injectable routes in animal models, though it is supplied and discussed here as an injectable research compound. Given the early stage of research, claims about cognitive benefit in humans should be treated with substantial caution. Reported benefits include preclinical models report potent effects on synapse formation at very low doses, explored as a research tool for models of cognitive impairment, investigated for potential neuroregenerative activity after neuronal injury in animal studies.
What is a typical Dihexa dose?
Reported ranges run 5-20 mcg. A low protocol is 5 mcg once daily, and a high protocol is 20 mcg once daily. This is reference information, not a dosing recommendation.
What is the half life of Dihexa?
Specific human pharmacokinetic data are not available; animal studies suggest activity at very low systemic exposure, but a defined half-life has not been established in humans.. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is Dihexa administered?
Subcutaneous: into fat, under the skin. Some early research examined oral and transdermal delivery; this profile reflects subcutaneous injection, consistent with standard research administration on this site.
How long is a Dihexa cycle?
3-4 weeks on, followed by 4 or more weeks off. No validated cycling protocol exists; any schedule discussed in research or vendor contexts is speculative given the near-absence of human trial data.
What are the side effects of Dihexa?
Reported side effects include human safety data are essentially unavailable, theoretical concern regarding unchecked growth-factor pathway activation, injection site irritation with subcutaneous use, unknown long-term risk profile given its potency at low doses. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Dihexa may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →