CJC-1295 (with DAC)
Also known as CJC-1295, DAC:GRF
CJC-1295 with DAC is a modified growth hormone releasing hormone (GHRH) analog engineered with a Drug Affinity Complex that binds circulating albumin, dramatically extending its activity compared to unmodified GHRH. Early clinical research reported sustained elevations in growth hormone and IGF-1 over days to weeks following a single dose. It is widely used in research and community protocols as a long-acting alternative to shorter-acting GHRH analogs, often paired with a GHRP for a stronger combined effect. Its long clearance time means effects, and any side effects, can persist well after the last dose.
Reported benefits
- Sustained GH/IGF-1 elevation
- Improved recovery and sleep quality
- Supports lean mass over time
- Convenient low-frequency dosing
How it works
The Drug Affinity Complex (DAC) covalently binds circulating albumin, protecting the attached GHRH(1-29) analog from rapid enzymatic degradation and greatly extending its half-life. This produces continuous, low-level stimulation of pituitary GHRH receptors, leading to a sustained rise in GH and IGF-1 rather than the discrete pulses seen with short-acting GHRH analogs.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 1,000 mcg | once weekly |
| Moderate | 2,000 mcg | once weekly |
| High | 2,000 mcg | twice weekly |
Estimate your dose
Dose estimator
Educational estimate for CJC-1295 (with DAC), scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for CJC-1295 (with DAC). Educational only.
Draw to this mark
40units
= 0.4 mL for a 2,000 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
5
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Commonly paired with a GHRP (such as Ipamorelin or GHRP-2) dosed separately to add pulsatile amplification on top of its sustained baseline elevation.
Common protocols
Common questions
What is CJC-1295 (with DAC) used for?
CJC-1295 with DAC is a modified growth hormone releasing hormone (GHRH) analog engineered with a Drug Affinity Complex that binds circulating albumin, dramatically extending its activity compared to unmodified GHRH. Early clinical research reported sustained elevations in growth hormone and IGF-1 over days to weeks following a single dose. It is widely used in research and community protocols as a long-acting alternative to shorter-acting GHRH analogs, often paired with a GHRP for a stronger combined effect. Its long clearance time means effects, and any side effects, can persist well after the last dose. Reported benefits include sustained gh/igf-1 elevation, improved recovery and sleep quality, supports lean mass over time.
What is a typical CJC-1295 (with DAC) dose?
Reported ranges run 1,000-2,000 mcg. A low protocol is 1,000 mcg once weekly, and a high protocol is 2,000 mcg twice weekly. This is reference information, not a dosing recommendation.
What is the half life of CJC-1295 (with DAC)?
~8 days. That is what sets the dosing frequency, and it is why the timing guidance is ~30 min before bed, empty stomach.
How is CJC-1295 (with DAC) administered?
Subcutaneous: into fat, under the skin. Injected subcutaneously; long half-life allows once- or twice-weekly dosing
How long is a CJC-1295 (with DAC) cycle?
12-16 weeks on, followed by 4-8 weeks off. Long clearance means effects persist for weeks after stopping, so off-periods are extended accordingly
What are the side effects of CJC-1295 (with DAC)?
Reported side effects include water retention, injection-site irritation, mild flushing or numbness after dosing, possible joint discomfort, fatigue at high doses. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. CJC-1295 (with DAC) may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →