Buserelin
Also known as Suprefact
Buserelin is a synthetic GnRH agonist used for androgen suppression in advanced prostate cancer, symptom control in endometriosis, and pituitary downregulation in some assisted-reproduction protocols. It follows the class-typical pattern of an initial hormonal flare followed by sustained suppression with continued dosing. Regulatory approval and specific formulations vary by country. It is a prescription-only hormonal therapy administered under medical supervision.
Reported benefits
- Androgen suppression in prostate cancer
- Reduction of endometriosis-related pain
- Pituitary desensitization in IVF stimulation protocols
- Established alternative within the GnRH agonist class
How it works
Continuous GnRH receptor agonism at the pituitary initially stimulates, then downregulates and desensitizes, gonadotrope GnRH receptors, reducing LH/FSH secretion and consequently lowering testosterone or estrogen production over several weeks.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 200 mcg | once daily, maintenance phase |
| Moderate | 500 mcg | three times daily during the initial 7-day induction phase |
| High | 1,000 mcg | daily total during induction (divided doses) |
Estimate your dose
Dose estimator
Educational estimate for Buserelin, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Buserelin. Educational only.
Draw to this mark
10units
= 0.1 mL for a 500 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
20
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Common protocols
Common questions
What is Buserelin used for?
Buserelin is a synthetic GnRH agonist used for androgen suppression in advanced prostate cancer, symptom control in endometriosis, and pituitary downregulation in some assisted-reproduction protocols. It follows the class-typical pattern of an initial hormonal flare followed by sustained suppression with continued dosing. Regulatory approval and specific formulations vary by country. It is a prescription-only hormonal therapy administered under medical supervision. Reported benefits include androgen suppression in prostate cancer, reduction of endometriosis-related pain, pituitary desensitization in ivf stimulation protocols.
What is a typical Buserelin dose?
Reported ranges run 200-1,000 mcg. A low protocol is 200 mcg once daily, maintenance phase, and a high protocol is 1,000 mcg daily total during induction (divided doses). This is reference information, not a dosing recommendation.
What is the half life of Buserelin?
Approximately 1 to 2 hours for subcutaneous dosing; depot formulations extend effective duration. That is what sets the dosing frequency, and it is why the timing guidance is as directed by your clinician.
How is Buserelin administered?
Subcutaneous: into fat, under the skin. Subcutaneous is standard for induction and maintenance dosing; intranasal and intramuscular depot forms are marketed in some countries.
How long is a Buserelin cycle?
Per oncology or gynecologic protocol, months to years on, followed by Discontinued per prescriber decision off.
What are the side effects of Buserelin?
Reported side effects include initial disease flare, hot flashes, injection site reactions, reduced bone density with prolonged use, decreased libido. Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Buserelin may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →