BPC-157 / TB-500 Blend
Also known as BPC-157/TB-500 Stack, Wolverine Blend
This blend combines BPC-157, a synthetic peptide based on a partial sequence of a gastric-protective compound, with TB-500, a synthetic analog of the naturally occurring protein thymosin beta-4. It is one of the most widely referenced combined-peptide research protocols for soft-tissue recovery, pairing two peptides that are individually studied in preclinical and animal models for tissue repair, angiogenesis, and modulation of inflammation. Interest in combining them centers on the idea that BPC-157's localized gut- and tendon-related effects and TB-500's broader systemic tissue-repair signaling may address injury from complementary angles. Evidence for the fixed combination itself is limited; most available data comes from studies of each peptide separately rather than trials of the blend. It is not approved for human medical use, and claims about its effects should be considered preliminary.
Reported benefits
- Supports tendon and ligament tissue repair in preclinical research
- Associated with reduced local inflammation
- Studied for gut-lining and soft-tissue recovery
- Frequently used as a general injury-recovery research pairing
How it works
BPC-157 is studied for its proposed influence on angiogenesis and fibroblast activity at sites of tissue damage, partly through modulation of growth-factor and nitric-oxide signaling pathways. TB-500 is an actin-binding peptide thought to support the migration of repair-related cells, such as fibroblasts and endothelial cells, to injured tissue. Researchers combining the two describe the pairing as targeting both localized structural repair (BPC-157) and broader cell-migration and angiogenic support (TB-500), though the two mechanisms have not been directly compared in a single controlled study.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 250 mcg | once daily |
| Moderate | 500 mcg | once daily |
| High | 750 mcg | twice daily |
Estimate your dose
Dose estimator
Educational estimate for BPC-157 / TB-500 Blend, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for BPC-157 / TB-500 Blend. Educational only.
Draw to this mark
10units
= 0.1 mL for a 500 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
20
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Considered a foundational pairing in injury-recovery research; sometimes extended with GHK-Cu for skin- or collagen-focused protocols (see GLOW Blend) or further layered with KPV (see KLOW Blend).
Common protocols
Common questions
What is BPC-157 / TB-500 Blend used for?
This blend combines BPC-157, a synthetic peptide based on a partial sequence of a gastric-protective compound, with TB-500, a synthetic analog of the naturally occurring protein thymosin beta-4. It is one of the most widely referenced combined-peptide research protocols for soft-tissue recovery, pairing two peptides that are individually studied in preclinical and animal models for tissue repair, angiogenesis, and modulation of inflammation. Interest in combining them centers on the idea that BPC-157's localized gut- and tendon-related effects and TB-500's broader systemic tissue-repair signaling may address injury from complementary angles. Evidence for the fixed combination itself is limited; most available data comes from studies of each peptide separately rather than trials of the blend. It is not approved for human medical use, and claims about its effects should be considered preliminary. Reported benefits include supports tendon and ligament tissue repair in preclinical research, associated with reduced local inflammation, studied for gut-lining and soft-tissue recovery.
What is a typical BPC-157 / TB-500 Blend dose?
Reported ranges run 250-750 mcg. A low protocol is 250 mcg once daily, and a high protocol is 750 mcg twice daily. This is reference information, not a dosing recommendation.
What is the half life of BPC-157 / TB-500 Blend?
The two components differ substantially: BPC-157 is reported at roughly 4 hours, while TB-500 is described as persisting for a much longer duration, on the order of days, despite both being injected in the same shot.. That is what sets the dosing frequency, and it is why the timing guidance is morning, or split am/pm.
How is BPC-157 / TB-500 Blend administered?
Subcutaneous: into fat, under the skin. Typically injected subcutaneously into abdominal fat; some informal protocols place the BPC-157 portion closer to an injured joint or tendon, since TB-500 is proposed to act more systemically regardless of injection site.
How long is a BPC-157 / TB-500 Blend cycle?
4-6 weeks on, followed by 2-4 weeks off. Often cycled to align with the expected healing window of a specific injury rather than used on an ongoing basis.
What are the side effects of BPC-157 / TB-500 Blend?
Reported side effects include mild nausea, head rush or lightheadedness, injection site redness or irritation, lethargy (more often reported with tb-500). Evidence level for this compound is well studied.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. BPC-157 / TB-500 Blend may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →