ARA-290
Also known as Cibinetide
ARA-290, also studied under the name cibinetide, is a synthetic peptide designed to activate tissue-protective pathways associated with erythropoietin without stimulating red blood cell production. It has been investigated in clinical research for neuropathic pain, particularly in diabetic patients, and for its potential role in tissue repair and inflammation modulation. As a non-hematopoietic EPO analog, it is designed to engage the innate repair receptor while avoiding cardiovascular risks tied to traditional erythropoietin therapy. Clinical trials remain at a relatively early stage, and findings are considered preliminary.
Reported benefits
- Studied for neuropathic pain reduction in diabetic patients
- Investigated for nerve fiber density support
- Explored for anti-inflammatory activity in vascular tissue
- Studied for potential wound healing support in diabetic complications
- Researched for tissue-protective effects without erythropoietic activity
How it works
ARA-290 is believed to bind the innate repair receptor, a complex distinct from the classical erythropoietin receptor involved in red blood cell production. Activation of this receptor is thought to trigger anti-inflammatory and cytoprotective signaling in damaged nerve and vascular tissue. This selective activity is proposed to allow tissue-protective effects without the erythropoietic side effects of standard EPO analogs.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 1,000 mcg | once daily |
| Moderate | 2,000 mcg | once daily |
| High | 4,000 mcg | once daily |
Estimate your dose
Dose estimator
Educational estimate for ARA-290, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for ARA-290. Educational only.
Draw to this mark
40units
= 0.4 mL for a 2,000 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
5
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Common protocols
Common questions
What is ARA-290 used for?
ARA-290, also studied under the name cibinetide, is a synthetic peptide designed to activate tissue-protective pathways associated with erythropoietin without stimulating red blood cell production. It has been investigated in clinical research for neuropathic pain, particularly in diabetic patients, and for its potential role in tissue repair and inflammation modulation. As a non-hematopoietic EPO analog, it is designed to engage the innate repair receptor while avoiding cardiovascular risks tied to traditional erythropoietin therapy. Clinical trials remain at a relatively early stage, and findings are considered preliminary. Reported benefits include studied for neuropathic pain reduction in diabetic patients, investigated for nerve fiber density support, explored for anti-inflammatory activity in vascular tissue.
What is a typical ARA-290 dose?
Reported ranges run 1,000-4,000 mcg. A low protocol is 1,000 mcg once daily, and a high protocol is 4,000 mcg once daily. This is reference information, not a dosing recommendation.
What is the half life of ARA-290?
Short half-life estimated at under 1 hour based on early pharmacokinetic research. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is ARA-290 administered?
Subcutaneous: into fat, under the skin.
How long is a ARA-290 cycle?
4-8 weeks on, followed by 4 weeks off. Cycling protocols are not well established given the early stage of clinical research.
What are the side effects of ARA-290?
Reported side effects include injection site reaction, headache, mild flushing, limited long-term safety data from early-stage trials. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. ARA-290 may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →