Alpha-MSH
Also known as Alpha-Melanocyte-Stimulating Hormone
Alpha-MSH is a naturally occurring 13-amino-acid peptide hormone derived from proopiomelanocortin, best known for stimulating melanin production but also studied for broad anti-inflammatory and immunomodulatory properties. Research spans its roles in skin pigmentation, appetite regulation, and systemic inflammation control. Synthetic analogs of alpha-MSH have been explored clinically for conditions such as erythropoietic protoporphyria, though alpha-MSH itself is used mainly in research settings. Effects can vary meaningfully depending on which melanocortin receptor subtype is engaged.
Reported benefits
- Studied for broad anti-inflammatory and immunomodulatory effects
- Explored for skin pigmentation and photoprotection research
- Investigated in models of systemic inflammatory conditions
- May support appetite and stress-response regulation via central melanocortin pathways
How it works
Alpha-MSH binds melanocortin receptors, particularly MC1R and MC3R, which are expressed on immune cells as well as melanocytes. Engagement of these receptors is associated with downregulation of pro-inflammatory cytokines and suppression of NF-kB activity, contributing to its studied anti-inflammatory profile. Through MC1R on melanocytes, it also stimulates melanogenesis, which accounts for its tanning-related use.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 250 mcg | daily |
| Moderate | 500 mcg | daily |
| High | 1,000 mcg | daily |
Estimate your dose
Dose estimator
Educational estimate for Alpha-MSH, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for Alpha-MSH. Educational only.
Draw to this mark
10units
= 0.1 mL for a 500 mcg dose
Concentration
5,000 mcg/mL
Doses per vial
20
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Sometimes discussed alongside melanotan analogs for pigmentation research, and alongside KPV for anti-inflammatory focus
Common protocols
Common questions
What is Alpha-MSH used for?
Alpha-MSH is a naturally occurring 13-amino-acid peptide hormone derived from proopiomelanocortin, best known for stimulating melanin production but also studied for broad anti-inflammatory and immunomodulatory properties. Research spans its roles in skin pigmentation, appetite regulation, and systemic inflammation control. Synthetic analogs of alpha-MSH have been explored clinically for conditions such as erythropoietic protoporphyria, though alpha-MSH itself is used mainly in research settings. Effects can vary meaningfully depending on which melanocortin receptor subtype is engaged. Reported benefits include studied for broad anti-inflammatory and immunomodulatory effects, explored for skin pigmentation and photoprotection research, investigated in models of systemic inflammatory conditions.
What is a typical Alpha-MSH dose?
Reported ranges run 250-1,000 mcg. A low protocol is 250 mcg daily, and a high protocol is 1,000 mcg daily. This is reference information, not a dosing recommendation.
What is the half life of Alpha-MSH?
Short, estimated at approximately 30-60 minutes. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is Alpha-MSH administered?
Subcutaneous: into fat, under the skin.
How long is a Alpha-MSH cycle?
4-6 weeks on, followed by 4 weeks off. Cycling is commonly used to limit pigmentation buildup and reassess tolerance
What are the side effects of Alpha-MSH?
Reported side effects include nausea, especially at higher doses, flushing, increased skin pigmentation (may be undesired outside intended use), appetite changes, rare mood or libido effects related to central melanocortin activity. Evidence level for this compound is moderate evidence.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. Alpha-MSH may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →