5-Amino-1MQ
Also known as 5-Amino-1-Methylquinolinium
5-Amino-1MQ is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), studied for a potential role in body composition and metabolic regulation. It is a synthetic quinolinium derivative rather than a peptide, and it gained early attention from preclinical obesity research conducted at Washington University. Interest has since spread into broader metabolic-health and longevity communities, largely through oral capsule formulations. Because NNMT activity is concentrated in adipose and liver tissue, research has focused on fat-cell energy metabolism rather than central nervous system effects. Human clinical trials remain limited, so claims about fat loss or metabolic benefit in people should be treated as unconfirmed.
Reported benefits
- Explored for supporting increased energy expenditure in fat cells
- Studied for potential fat-mass reduction in obesity research models
- Investigated for effects on NAD+ and SAMe balance via NNMT inhibition
- Notable for favorable oral bioavailability compared with most peptide-based options
How it works
NNMT converts nicotinamide into methylnicotinamide, a reaction that consumes both nicotinamide, an NAD+ precursor, and the methyl donor SAMe. By inhibiting NNMT, 5-Amino-1MQ is theorized to preserve more nicotinamide for NAD+ synthesis and reduce methylnicotinamide buildup in fat and liver tissue. In rodent studies this shift has been associated with increased cellular energy expenditure and reduced fat mass, though translation of these pathways to humans has not been established.
Dosing ranges
| Tier | Dose | Frequency |
|---|---|---|
| Low | 50 mg | once daily |
| Moderate | 100 mg | once daily |
| High | 150 mg | once daily |
Estimate your dose
Dose estimator
Educational estimate for 5-Amino-1MQ, scaled to body size. Not medical advice.
Read before using
This tool produces a rough, educational estimate by scaling commonly-published research ranges to lean body mass. It is not a prescription, medical advice, or a substitute for a licensed clinician. Most peptides use fixed dosing, not weight-based dosing. Individual needs vary. You are solely responsible for how you use this information.
Mixing & syringe units
Target dose follows the estimate above. Change it there, or edit it directly below.
Reconstitution calculator
How much water to add and how many insulin-syringe units to draw for 5-Amino-1MQ. Educational only.
Draw to this mark
2,000units
= 20 mL for a 100 mg dose
Concentration
5 mg/mL
Doses per vial
0
This dose needs 2,000 units, more than a 100-unit syringe holds. Add more water, split the dose, or use a larger syringe.
A U-100 syringe reads 100 units per mL. This is a reconstitution math helper only, not a prescription or dosing advice. Verify every calculation and consult a qualified healthcare provider.
Possible side effects
Stacking notes
Sometimes combined with other fat-loss-focused peptides such as AOD-9604; oral use is generally preferred over injectable forms. No controlled data exist on combined use.
Common protocols
Common questions
What is 5-Amino-1MQ used for?
5-Amino-1MQ is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), studied for a potential role in body composition and metabolic regulation. It is a synthetic quinolinium derivative rather than a peptide, and it gained early attention from preclinical obesity research conducted at Washington University. Interest has since spread into broader metabolic-health and longevity communities, largely through oral capsule formulations. Because NNMT activity is concentrated in adipose and liver tissue, research has focused on fat-cell energy metabolism rather than central nervous system effects. Human clinical trials remain limited, so claims about fat loss or metabolic benefit in people should be treated as unconfirmed. Reported benefits include explored for supporting increased energy expenditure in fat cells, studied for potential fat-mass reduction in obesity research models, investigated for effects on nad+ and same balance via nnmt inhibition.
What is a typical 5-Amino-1MQ dose?
Reported ranges run 50-150 mg. A low protocol is 50 mg once daily, and a high protocol is 150 mg once daily. This is reference information, not a dosing recommendation.
What is the half life of 5-Amino-1MQ?
Approximately 8 hours, based on limited pharmacokinetic data.. That is what sets the dosing frequency, and it is why the timing guidance is morning.
How is 5-Amino-1MQ administered?
Oral: by mouth. Most commonly taken as an oral capsule; some vendors offer subcutaneous formulations, but oral use is far more established in practice.
How long is a 5-Amino-1MQ cycle?
4-12 weeks on, followed by Break before repeating (specific duration not well established) off. Daily oral dosing is typical; standardized cycling protocols have not been established in controlled research.
What are the side effects of 5-Amino-1MQ?
Reported side effects include mild gastrointestinal discomfort reported anecdotally, occasional headache, limited long-term human safety data, theoretical concern about methyl-donor (same) depletion with prolonged use. Evidence level for this compound is emerging research.
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Educational use only, not medical advice. This profile is provided for research and educational purposes. 5-Amino-1MQ may be a research compound or a prescription medication; nothing here is intended to diagnose, treat, cure, or prevent any disease. Dosing figures reflect commonly-published research ranges, not a prescription. Consult a qualified healthcare provider before making any health decision. Read the full disclaimer →