# Vapreotide

> Vapreotide is a synthetic somatostatin analog with affinity for SSTR2 and SSTR5 receptors, studied primarily for acute esophageal variceal bleeding and for symptom control in neuroendocrine tumors. Compared with octreotide and lanreotide, it has more limited and geographically restricted regulatory approval, and it is not available in all markets. Clinical evidence is more limited than for the more widely used somatostatin analogs, so its role in practice remains narrower.

- URL: https://www.lifeconverted.com/peptides/vapreotide
- Also known as: Sanvar
- Primary category: Other & Clinical
- Effectiveness rank: #12 in Other & Clinical
- Evidence level: Moderate evidence
- Route: Subcutaneous (Primarily studied as an intravenous infusion for acute esophageal variceal bleeding; subcutaneous dosing has been studied for other indications. It is not FDA-approved in the United States and has narrower regulatory approval than octreotide or lanreotide.)
- Dose range: 50-100 mcg
- Dose tiers: low 50 mcg; moderate 50 mcg; high 100 mcg
- Half-life: Approximately 30 to 70 minutes
- Timing: As directed by your clinician
- Cycle: Acute short-course therapy over days for variceal bleeding on, Discontinued once bleeding is controlled off (Not typically used as a chronic, self-administered peptide.)
- Storage: Refrigerate at 2-8°C, protect from light, and reconstitute immediately before use.

## Mechanism of action

Vapreotide binds somatostatin receptor subtypes 2 and 5, reducing splanchnic blood flow and portal pressure while inhibiting secretion of growth hormone and various gastrointestinal hormones, similar in principle to other somatostatin analogs but with a distinct receptor-affinity profile.

## Reported benefits

- Studied for reduction of acute variceal hemorrhage
- Investigated for control of neuroendocrine tumor-related secretory symptoms

## Reported side effects

- Gastrointestinal disturbance
- Hyperglycemia
- Injection or infusion site reactions
- Bradycardia
- Gallbladder effects with prolonged use

## Common protocols

- Acute esophageal variceal bleeding IV infusion protocol
- Investigational neuroendocrine tumor symptom control

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