# Selank

> Selank is a synthetic peptide derived from tuftsin, a naturally occurring immunomodulatory tetrapeptide, with an added proline-glycine-proline sequence intended to improve enzymatic stability. Developed in Russia, it has been studied primarily as an anxiolytic with reported mild nootropic properties, positioned in that research tradition as an alternative to benzodiazepines that does not appear to cause sedation or dependence in available studies. Research includes small clinical trials for generalized anxiety and adjustment-related symptoms conducted largely in Russian populations, with limited independent replication elsewhere. It is not approved for medical use in the United States and is available mainly as a research compound. As with related peptides in this class, human data remain preliminary and warrant cautious interpretation.

- URL: https://www.lifeconverted.com/peptides/selank
- Primary category: Cognitive & Neuro
- Effectiveness rank: #4 in Cognitive & Neuro
- Evidence level: Well studied
- Route: Subcutaneous (Historically administered intranasally in Russian clinical and research use; this profile reflects subcutaneous injection as used in current research contexts.)
- Dose range: 250-750 mcg
- Dose tiers: low 250 mcg; moderate 500 mcg; high 750 mcg
- Half-life: Reported to be short, on the order of minutes to roughly an hour in plasma, though downstream neurochemical effects may persist longer than the peptide's detectable presence.
- Timing: Morning
- Cycle: 4-8 weeks on, 2-4 weeks off (No controlled studies have established an optimal cycling schedule; breaks are discussed informally to limit theoretical tolerance.)
- Storage: Store lyophilized peptide refrigerated (2-8°C) or frozen prior to reconstitution, protected from light. After reconstitution, keep refrigerated and use within about 2-4 weeks.

## Mechanism of action

Selank is proposed to modulate GABAergic and serotonergic signaling alongside effects on brain-derived neurotrophic factor (BDNF) expression, which may underlie its reported anxiolytic and cognitive effects. It has also been studied for effects on cytokine expression, including modulation of interleukin-6, suggesting a possible link between its central effects and immune signaling. The precise receptor-level mechanism has not been fully characterized in humans.

## Reported benefits

- Studied for anxiolytic effects without apparent sedation
- Explored for mild nootropic effects on attention and mental stamina
- Reported to support stress resilience in some research settings
- May modulate immune-related cytokine signaling
- Non-addictive profile reported across available studies

## Reported side effects

- Injection site reactions with subcutaneous use
- Mild headache reported in some users
- Limited data on long-term or high-dose safety
- Possible interaction with other central nervous system-acting compounds

## Common protocols

- Daily morning or divided dosing during periods of situational stress in research settings
- Short multi-week research courses

## Stacking notes

Frequently paired with Semax in research discussions targeting combined anxiolytic and cognitive effects; no controlled data support specific combinations.

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Educational information only, not medical advice. Full disclaimer: https://www.lifeconverted.com/disclaimer