# Buserelin

> Buserelin is a synthetic GnRH agonist used for androgen suppression in advanced prostate cancer, symptom control in endometriosis, and pituitary downregulation in some assisted-reproduction protocols. It follows the class-typical pattern of an initial hormonal flare followed by sustained suppression with continued dosing. Regulatory approval and specific formulations vary by country. It is a prescription-only hormonal therapy administered under medical supervision.

- URL: https://www.lifeconverted.com/peptides/buserelin
- Also known as: Suprefact
- Primary category: Other & Clinical
- Effectiveness rank: #6 in Other & Clinical
- Evidence level: Well studied
- Route: Subcutaneous (Subcutaneous is standard for induction and maintenance dosing; intranasal and intramuscular depot forms are marketed in some countries.)
- Dose range: 200-1,000 mcg
- Dose tiers: low 200 mcg; moderate 500 mcg; high 1000 mcg
- Half-life: Approximately 1 to 2 hours for subcutaneous dosing; depot formulations extend effective duration
- Timing: As directed by your clinician
- Cycle: Per oncology or gynecologic protocol, months to years on, Discontinued per prescriber decision off
- Storage: Refrigerate at 2-8°C and protect from light.

## Mechanism of action

Continuous GnRH receptor agonism at the pituitary initially stimulates, then downregulates and desensitizes, gonadotrope GnRH receptors, reducing LH/FSH secretion and consequently lowering testosterone or estrogen production over several weeks.

## Reported benefits

- Androgen suppression in prostate cancer
- Reduction of endometriosis-related pain
- Pituitary desensitization in IVF stimulation protocols
- Established alternative within the GnRH agonist class

## Reported side effects

- Initial disease flare
- Hot flashes
- Injection site reactions
- Reduced bone density with prolonged use
- Decreased libido

## Common protocols

- Prostate cancer androgen suppression
- Endometriosis management
- Pituitary downregulation in IVF cycles

---

Educational information only, not medical advice. Full disclaimer: https://www.lifeconverted.com/disclaimer